This update of a classic text folds the new field of neuroscience for design into well-established environment-behavior (E-B) methods and approaches. Illustrated evidence-based building and open space case studies demonstrate E-B’s continuing design impact. Fundamental theory and practical research methods are presented for planning, programming, designing, and evaluating the effects of physical environments in use. Part I describes how designers and researchers employ a similar creative process that promotes collaboration and yields greater design creativity and research effectiveness. Part II focuses on research methods to understand how buildings and spaces work: observing behavior and the physical environment, asking questions in interviews and surveys, and employing archival records that include data and physical plans. 50 illustrations.